Mastocytes derived or recombinant mouse mast cell protease 4 (mMCP-4) converts big-ET-1 to ET-1 (1-31)
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چکیده
منابع مشابه
Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.
The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II) from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1-31) from Big-ET-1. Although humans possess only one chymase, several murine isoforms are documented, each with its own specific catalytic activity. Among these, mouse mast cell protease 4 (mMCP-4) is the isoform most simil...
متن کاملPivotal Role of Mouse Mast Cell Protease 4 in the Conversion and Pressor Properties of Big-Endothelin-1 s
The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II) from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1–31) from Big-ET-1. Although humans possess only one chymase, several murine isoforms are documented, each with its own specific catalytic activity. Among these, mouse mast cell protease 4 (mMCP-4) is the isoform most simil...
متن کاملMouse mucosal mast cell protease 4 generates endothelin-1 in vitro and in vivo
Martin Houde, Julie Labonté, Marc-David Jamain, Gunnar Pejler, Michael Gurish, Shinji Takai, Pedro D'Orléans-Juste. Université de Sherbrooke, Département de Pharmacologie, J1H 5N4, Canada, Swedish University of Agricultural Sciences, Department of Anatomy, Biology and Biochemistry, SE-750 07, Sweden, Brigham and Women's Hospital, Department of Rheumatology, 02115, United States, Osaka Medical C...
متن کاملInsulin sensitivity and big ET-1 conversion to ET-1 after ETA- or ETB-receptor blockade in humans.
Cardiovascular diseases are characterized by insulin resistance and elevated endothelin (ET)-1 levels. Furthermore, ET-1 induces insulin resistance. To elucidate this mechanism, six healthy subjects were studied during a hyperinsulinemic euglycemic clamp during infusion of (the ET-1 precursor) big ET-1 alone or after ET(A)- or ET(B)-receptor blockade. Insulin levels rose after big ET-1 with or ...
متن کاملRole of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.
The present study examined the roles of endothelin-converting enzyme (ECE), neutral endopeptidase (NEP) and mast cell chymase as processors of the endothelin (ET) analogues ET-1(1-21), ET-1(1-31) and big ET-1 in the trachea of allergic mice. Male CBA/CaH mice were sensitized with ovalbumin (10 microg) delivered intraperitoneal on days 1 and 14, and exposed to aerosolized ovalbumin on days 14, 2...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2013
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2013.12.132